Bile acid sequestrants interfere with the absorption of fat-soluble vitamins; supplements of vitamins A, D, K, and folic acid may be required when treatment is prolonged.
- Oral powder sachets sugar free 4g (£88.35 = 12g daily)
Indications and Dose
- Reduction of plasma cholesterol in hypercholesterolaemia, such as in Fredrickson's Type II
- Initially 4g daily, increase by 4g at weekly intervals to 12–24g daily in 1–4 divided doses, adjusted according to response; maximum 36g daily
- Diarrhoea associated with Crohn’s disease
- Initially 4g daily, increased by 4g at weekly intervals to 12–24g daily in 1–4 divided doses, then adjusted as required; maximum 36g daily
- Pruritus associated with partial biliary obstruction and primary biliary cirrhosis
- For use in familial hypercholesterolaemia, see NICE guidance (CG71) Familial hypercholesterolaemia. NICE guidance CG181 states that a bile acid sequestrant should not be offered for the prevention of CVD to people being treated for primary or secondary prevention, people with CKD or type 1 diabetes or type 2 diabetes.
- Colestyramine is a potent cholesterol-lowering agent; it is recommended only for people who cannot tolerate other agents.
- Doses of more than 24g a day of colestyramine resin may interfere with normal fat absorption.
- Manufacturer advises take other drugs at least 1 hour before, or 4–6 hours after, colestyramine due to the potential for interaction. Refer to the individual Summary of Product Characteristics for further details.
- Tablets 625mg (£115.32 = 180 pack)
- Colesevelam is included for the treatment of bile salt diarrhoea (off-label use) only in patients unable to tolerate colestyramine.
- Colesevelam has not been approved locally for the treatment of hypercholesterolaemia.
- Manufacturer advises take 4 hours before, or after, other drugs due to the potential for interaction. Refer to the individual Summary of Product Characteristics for further details.
1. Gastrointestinal >
1.9 Drugs affecting intestinal secretions >
1.9.2 Bile acid sequestrants
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