5.1.11 Nitroimidazole derivatives

Alcohol should be avoided for 72 hours after tinidazole and at least 48 hours after metronidazole treatment, because of the possibility of a disulfiram-like reaction (flushing, abdominal cramps, vomiting, tachycardia).

Metronidazole

• Tablets 200mg, 400mg (£1.83, £5.47 = 21 tablets)
• Suspension 200mg/5ml (£35.22 = 100ml)
• Suppositories 500mg, 1g (£15.18, £23.06 = 10)
• Intravenous infusion 100mg/20ml, 500mg/100ml

Indications

• Acute necrotising ulcerative gingivitis
• Bacterial vaginosis
• Bites (animal and human) - with doxycycline (second line)
• Dental abscess
• Eradication of H. pylori
• Giardiasis
• Mild / moderate C. difficile disease
• Pelvic inflammatory disease - with doxycycline or levofloxacin (second line)
• Pericoronitis
• Trichomoniasis

Tinidazole

• Tablets 500mg (£11.04 = 16 tablets)

Indications

• Giardiasis

 

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• First line
• Second line
• Specialist
• Hospital