- Capsules 250mg
- Injection 1g
- Tablets 250mg (£6.02 = 10 tablets)
- Fusidic acid oral suspension 250mg/5ml (5ml is approximately equivalent to 175mg sodium fusidate) (£6.73 = 50ml)
- Infections caused by staphylococci, especially in osteomyelitis
- MHRA Drug Safety Update (September 2011): Systemic fusidic acid and interaction with statins
- Systemic fusidic acid should not be given with statins because of a risk of (potentially fatal) rhabdomyolysis
- In patients for whom the use of systemic fusidic acid is essential, statin treatment should be temporarily discontinued throughout the duration of fusidic acid treatment. To ensure clearance of systemic fusidic acid, statin therapy may be reintroduced 7 days after the last dose of systemic fusidic acid
- Capsules 125mg, 250mg (£132.49 = 28 x 125mg capsules)
- Powder for solution for infusion vials 500mg, 1g
- Intrathecal injection 10mg/2ml (unlicensed preparation)
- The intravenous route should not be used for C. difficile infections. Alternative oral formulations may be available, seek specialist advice
- Therapeutic drug monitoring (serum-vancomycin measurement) is required for intravenous use
- Powder for concentrate for solution for infusion 500mg vial
- Tablets 200mg (£1,350.00 = 20 tablets)
Indications and dose
- The routine commissioning of fidaxomicin is accepted in Devon for the treatment of Clostridioides difficile infection (see Commissioning Policy for more details)
- Intravenous infusion 350mg, 500mg vials
- Tablets 600mg
- Suspension 100mg/5ml
- Intravenous infusion 600mg/300ml
- Monitor full blood count (including platelet count) weekly.
- Linezolid should only be initiated in a hospital environment and after consultation with a relevant specialist such as a microbiologist. In exceptional circumstances it may be considered appropriate for a GP to commence treatment in a primary care setting (off-license use), only under the recommendation and supervision of a microbiologist. This should be discussed on an individual patient basis.
- Linezolid should only be used for life-threatening or deep seated infections due to MRSA where alternate therapy, e.g. vancomycin, is unsuitable. Linezolid is not active against infections caused by Gram negative pathogens. Specific therapy against Gram negative organisms must be initiated concomitantly if a Gram negative pathogen is documented or suspected.
- The maximum treatment duration is 28 days. The safety and effectiveness of linezolid when administered for periods longer than 28 days have not been established.
- BNF CHM advice
Severe optic neuropathy may occur rarely, particularly if linezolid is used for longer than 28 days. The CHM recommends that:
- patients should be warned to report symptoms of visual impairment (including blurred vision, visual field defect, changes in visual acuity and colour vision) immediately;
- patients experiencing new visual symptoms (regardless of treatment duration) should be evaluated promptly, and referred to an ophthalmologist if necessary;
- visual function should be monitored regularly if treatment is required for longer than 28 days.
Haematopoietic disorders (including thrombocytopenia, anaemia, leucopenia, and pancytopenia) have been reported in patients receiving linezolid. It is recommended that full blood counts are monitored weekly. Close monitoring is recommended in patients who:
If significant myelosuppression occurs, treatment should be stopped unless it is considered essential, in which case intensive monitoring of blood counts and appropriate management should be implemented.
- receive treatment for more than 10–14 days;
- have pre-existing myelosuppression;
- are receiving drugs that may have adverse effects on haemoglobin, blood counts, or platelet function;
- have severe renal impairment.
- Spontaneous reports of serotonin syndrome associated with the co-administration of linezolid and serotonergic agents, including antidepressants such as selective serotonin reuptake inhibitors (SSRIs) have been reported. Co-administration of linezolid and serotonergic agents is therefore contraindicated except where administration of linezolid and concomitant serotonergic agents is essential. In those cases patients should be closely observed for signs and symptoms of serotonin syndrome.
For additional interaction and monitoring requirements associated with treatment, please refer to the manufacturer's
summary of product characteristics for up-to-date information.
- Injection 500,000 units, 1million-units, 2million-units
- Colobreathe® 1,662,500 unit dry powder for inhalation (Cystic Fibrosis (CF) treatment only)
- Promixin® 1 million unit powder for nebuliser solution (CF treatment only)
- For patients with CysticFibrosis (CF): treatment should only be prescribed by secondary care
- Non-CF bronchiectasis patients: Colistimethate sodium powder for solution for injection is included for nebulised use in this patient group (unlicensed)
- National commissioning criteria for inhaled treatments for CF can be found in the NHS England commissioning policy, available here
- NICE TA276: Colistimethate sodium and tobramycin dry powders for inhalation for treating pseudomonas lung infection in cystic fibrosis (March 2013):
- Colistimethate sodium DPI (Colobreathe) is recommended as an option for treating chronic pulmonary infection caused by Pseudomonas aeruginosa in people with CF only if the criteria within the NICE TA are met
- Tablets 550mg (£259.23 = 56 tablets)
- 550mg twice a day
- The clinical benefit of rifaximin was established from a controlled study in which subjects were treated for 6 months. Treatment beyond 6 months should take into consideration the individual balance between benefits and risks, including those associated with the progression of hepatic dysfunction.
- Rifaximin should be co-prescribed alongside lactulose (or alternative laxative) sufficient to open bowels twice per day.
- Treatment with rifaximin should be initiated by a Gastroenterology Consultant. Once the patient is stabilised on treatment repeat prescriptions may be issued by primary care, however the ongoing management of the patient's liver disease will continue to be the responsibility of secondary care.
- Rifaximin is a non-absorbed antibacterial agent and there are no specific monitoring requirements associated with treatment.
- Secondary care will monitor the ongoing need for continuation of rifaximin in individual patients
- NICE TA337 Rifaximin is recommended, within its marketing authorisation, as an option for reducing the recurrence of episodes of overt hepatic encephalopathy in people aged 18 years or older (March 2015).
- Tablets 200mg
- Powder for concentrate for solution for infusion 200 mg
5. Infections >
5.1 Antibacterial drugs >
5.1.7 Some other antibacterials
- First line
- Second line