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Further guidance supporting the prescribing of HRT preparations and the clinical management of menopause can be found here: Guidance on the management of menopause.
For women without a uterus or cervix, oestrogen-only HRT is appropriate, however, in endometriosis, endometrial foci may remain despite hysterectomy and the addition of a progestogen should be considered in these circumstances.
For women with a uterus, oestrogen plus progestogen HRT is required. In women with a subtotal hysterectomy (retaining their cervix), oestrogen plus progesterone may be required*. A progestogen should be added to reduce the risk of cystic hyperplasia of the endometrium and possible transformation to cancer.
For use in the perimenopause or within 12 months of the last menstrual period, a sequential (cyclical) combined regimen is recommended.
For postmenopausal women whose last menstrual period occurred over 12 months previously, a continuous combined regimen is recommended.
* There is limited evidence to guide practice in relation to the role or need for progestogen replacement in women who have had subtotal hysterectomy. British Menopause Society guidance suggests considering oestrogen plus sequential progestogen for up to 3 months:
If this results in monthly bleeding, endometrial cells are present and are responding to the hormones, therefore oestrogen plus progestogen HRT should be used thereafter. If a woman would like to avoid monthly bleeding, continuous combined HRT is advised.
If there is no bleeding, it is unlikely that residual endometrium is present and oestrogen only HRT can be used.
A number of the doses in this table are off-label (refer to individual product entries for licensed indications & doses).
Route of administration
Consider transdermal rather than oral HRT for menopausal women who are at increased risk of venous thromboembolism (VTE) including those with a BMI over 30kg/m2. Consider referring those at high risk (strong family history of VTE or a hereditary thrombophilia) to a haematologist for assessment before considering HRT.
The transdermal route should also be considered when oral treatment is not sufficiently effective or is not tolerated, or if the individual has cardiovascular risk factors (e.g. obesity, uncontrolled hypertension, or hypertriglyceridaemia) or a gastrointestinal disorder that may affect absorption of oral treatment, or has a history of migraine or gallbladder disease, or is taking concomitant hepatic enzyme-inducing drug treatment.
Women with a uterus require addition of a progestogen (see above).
Oral
Elleste solo
(Estradiol)
Tablets 1mg, 2mg (£5.06 = 84 tablets)
Indications and dose
Menopausal symptoms
1mg daily, increased if necessary to 2mg daily
Osteoporosis prophylaxis in postmenopausal women
2mg daily
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients).
Start treatment on day 1 of menstruation (or at any time if cycles have ceased or are infrequent).
For women with a uterus, oestrogen plus progestogen HRT is required. In women with a subtotal hysterectomy (retaining their cervix), oestrogen plus progesterone may be required (see introductory section above).
Transdermal
Consider transdermal rather than oral HRT for menopausal women who are at increased risk of VTE, including those with a BMI over 30kg/m2. Consider referring those at high risk (strong family history of VTE or a hereditary thrombophilia) to a haematologist for assessment before considering HRT.
The transdermal route should also be considered when oral treatment is not sufficiently effective or is not tolerated, or if the individual has cardiovascular risk factors (e.g. obesity, uncontrolled hypertension, or hypertriglyceridaemia) or a gastrointestinal disorder that may affect absorption of oral treatment, or has a history of migraine or gallbladder disease, or is taking concomitant hepatic enzyme-inducing drug treatment.
Osteoporosis prophylaxis in postmenopausal women (minimum 50micrograms/24hours)
Dose
Apply 1 patch twice weekly continuously.
Start within 5 days of onset of menstruation (or at any time if cycles have ceased or are infrequent).
For women with a uterus, oestrogen plus progestogen HRT is required. In women with a subtotal hysterectomy (retaining their cervix), oestrogen plus progesterone may be required (see introductory section above).
Therapy should be initiated with Evorel 50 patch; subsequently adjust according to response; dose may be reduced to Evorel 25 patch after first month if necessary for menopausal symptoms only.
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients).
Evorel is first line in patients for whom the transdermal route is clinically indicated (see above)
Osteoporosis prophylaxis in postmenopausal women (minimum 50micrograms/24hours)
Dose
Apply 1 patch twice weekly continuously.
Start within 5 days of onset of menstruation (or at any time if cycles have ceased or are infrequent).
For women with a uterus, oestrogen plus progestogen HRT is required. In women with a subtotal hysterectomy (retaining their cervix), oestrogen plus progesterone may be required (see introductory section above).
For menopausal symptoms, therapy should be initiated with Estradot 25 patch for first 3 months; subsequently adjust according to response.
For osteoporosis prophylaxis, therapy should be initiated with Estradot 50 patch; subsequently adjust according to response.
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients)
Transdermal gel
Recommended as alternative option where the transdermal route is clinically indicated but Evorel transdermal patches are ineffective, not tolerated, or impractical.
Oestrogel Pump-Pack (2nd line transdermal)
(Estradiol)
Transdermal gel 0.06%, providing 750micrograms estradiol per 1.25g pump actuation (£6.17 = 80g (64 metered doses))
Indications and dose
Menopausal symptoms
Apply 1.5mg (2 pumps) once daily continuously, increased if necessary up to 3mg (4 pumps) once daily after 1 month of continuous treatment.
Osteoporosis prophylaxis in postmenopausal women
Apply 1.5mg (2 pumps) once daily continuously.
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients)
If switching from cyclical HRT, start at end of regimen; otherwise start at any time.
For women with a uterus, oestrogen plus progestogen HRT is required. In women with a subtotal hysterectomy (retaining their cervix), oestrogen plus progesterone may be required (see introductory section above).
To be applied over a large area. Apply gel to clean, dry, intact skin such as arms, shoulders or inner thighs and allow to dry for 5 minutes before covering with clothing. Not to be applied on or near breasts or on vulval region. Avoid skin contact with another person (particularly male) and avoid other skin products or washing the area for at least 1 hour after application.
Transdermal spray
Recommended as alternative option where the transdermal route is clinically indicated but transdermal patches (Evorel or Estradot) and Oestrogel are ineffective, not tolerated, or impractical.
Apply 1 spray once daily continuously, increased if necessary to 2 sprays once daily after at least 4 weeks of continuous treatment.
Maximum dose 3 sprays daily
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients).
For women with a uterus, oestrogen plus progestogen HRT is required. In women with a subtotal hysterectomy (retaining their cervix), oestrogen plus progesterone may be required (see introductory section above).
To be applied over a large area. Apply to dry, healthy skin of the inner forearm or alternatively the inner thigh and allow to dry for 2 minutes before covering with clothing. Avoid skin contact with another person (particularly children) or pets and avoid washing the area for at least 1 hour after application. If a sunscreen is needed, apply at least 1 hour before Lenzetto.
Lenzetto is not licensed or recommended for osteoporosis prophylaxis.
Oestrogen with progestogen
Continuous Combined Preparations
Continuous combined preparations are not suitable for use in the perimenopause or within 12 months of the last menstrual period.
Continuous combined regimens do not produce withdrawal bleeding, however irregular bleeding or spotting may occur in the first 4-6 months of treatment. If bleeding persists beyond 6 months of initiating (or 3 months after changing HRT preparation), becomes heavier, or occurs after a spell of amenorrhoea, endometrial pathology should be excluded, and consideration given to adjusting HRT. Refer to the British Menopause Society (BMS) guideline on management of unscheduled bleeding on HRT (April 2024) and the following Clinical Referral Guidelines:
Women with a uterus whose last menstrual period occurred over 12 months previously: 1 tablet daily continuously; if changing from cyclical HRT begin treatment at the end of scheduled bleed.
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients)
Kliovance
(Estradiol with norethisterone)
Tablets (1mg/500microgram) (£13.20 = 84 tablets)
Indications
Menopausal symptoms
Osteoporosis prophylaxis in postmenopausal women
Dose
Women with a uterus whose last menstrual period occurred over 12 months previously: 1 tablet daily continuously; start at end of scheduled bleed if changing from cyclical HRT
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients)
Osteoporosis prophylaxis in postmenopausal women (1mg/5mg strength only)
Dose
Women whose last menstrual period occurred over 12 months previously, 1 tablet daily continuously (if changing from cyclical HRT begin treatment the day after finishing oestrogen plus progestogen phase)
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients)
Femoston Conti is less androgenic.
Femoston products are included for patients experiencing troublesome progestogenic side effects with first line options.
Transdermal
Consider transdermal rather than oral HRT for menopausal women who are at increased risk of VTE, including those with a BMI over 30kg/m2. Consider referring those at high risk (strong family history of VTE or a hereditary thrombophilia) to a haematologist for assessment before considering HRT.
The transdermal route should also be considered when oral treatment is not sufficiently effective or is not tolerated, or if the individual has cardiovascular risk factors (e.g. obesity, uncontrolled hypertension, or hypertriglyceridaemia) or a gastrointestinal disorder that may affect absorption of oral treatment, or has a history of migraine or gallbladder disease, or is taking concomitant hepatic enzyme-inducing drug treatment.
1 patch to be applied twice weekly continuously, to be started at end of scheduled bleed if changing from cyclical HRT.
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients).
Evorel Conti is first line in patients for whom the transdermal route is clinically indicated (see above)
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients).
Sequential Combined Preparations (Cyclical HRT)
Sequential combined preparations are suitable for use in the perimenopause or within 12 months of the last menstrual period. They usually result in withdrawal bleeding at the end of each course of progestogen.
BMS guidance recommends that women taking sequential HRT over the age of 45 should be offered, after five years of use or by age 54 (whichever comes first), a change to continuous combined HRT.
Oral
Elleste Duet
(Estradiol with norethisterone)
Tablets 1mg and (1mg+1mg) (£9.20 = 84 tablets)
Tablets 2mg and (2mg+1mg) (£9.20 = 84 tablets)
Indications
Menopausal symptoms
Osteoporosis prophylaxis in postmenopausal women (2mg tablets only)
Dose
1 tablet (estradiol) daily for 16 days starting on day 1 of menstruation (or at any time if cycles have ceased or are infrequent), then 1 tablet (estradiol and norethisterone) daily for 12 days; subsequent courses are repeated without interval
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients)
Femoston
(Estradiol with dydrogesterone)
Femoston 1/10 tablets 1mg and (1mg+10mg) (£16.16 = 84 tablets)
Femoston 2/10 tablets 2mg and (2mg+10mg) (£16.16 = 84 tablets)
Indications
Menopausal symptoms
Osteoporosis prophylaxis in postmenopausal women
Dose
1 tablet (estradiol) daily for 14 days, starting within 5 days of onset of menstruation (or any time if cycles have ceased or are infrequent) then 1 tablet (estradiol and dydrogesterone) daily for 14 days; subsequent courses repeated without interval
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients)
Femoston is less androgenic.
Femoston products are recommended for patients experiencing troublesome progestogenic side effects with first line options.
Transdermal
Consider transdermal rather than oral HRT for menopausal women who are at increased risk of VTE, including those with a BMI over 30kg/m2. Consider referring those at high risk (strong family history of VTE or a hereditary thrombophilia) to a haematologist for assessment before considering HRT.
The transdermal route should also be considered when oral treatment is not sufficiently effective or is not tolerated, or if the individual has cardiovascular risk factors (e.g. obesity, uncontrolled hypertension, or hypertriglyceridaemia) or a gastrointestinal disorder that may affect absorption of oral treatment, or has a history of migraine or gallbladder disease, or is taking concomitant hepatic enzyme-inducing drug treatment.
Evorel Sequi
(Estradiol with norethisterone)
Transdermal patches 50micrograms/24hours and 50micrograms/170micrograms/24hours (£14.56 = 8 patches) (see note 3)
Indications
Menopausal symptoms
Osteoporosis prophylaxis in postmenopausal women
Dose
One Evorel 50 patch to be applied twice weekly for 2 weeks, starting within 5 days of onset of menstruation (or at any time if cycles have ceased or are infrequent), followed by one Evorel Conti patch twice weekly for 2 weeks; subsequent courses are repeated without interval.
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients)
Evorel Sequi is first line in patients for whom the transdermal route is clinically indicated (see above)
Each Evorel Sequi box contains 4 x Evorel 50 patches (estradiol only) and 4 x Evorel Conti patches (estradiol with norethisterone).
Progestogens
Progestogens act mainly on tissues sensitised by oestrogens and are used for menstrual disorders including severe dysmenorrhoea and menorrhagia.
Refer to 7.3.2.3 Intrauterine progestogen-only devices for levonorgestrel intrauterine devices (LNG-IUD) for contraception, menorrhagia and prevention of endometrial hyperplasia during oestrogen HRT.
Gepretix
(Micronised progesterone)
Oral capsules 100mg (£4.62 = 30 capsules)
Indications and dose
Progestogenic opposition of oestrogen HRT:
Sequential (cyclical) regimen: 200mg once daily on days 15–26 of each 28-day oestrogen HRT cycle. (licensed dose).
BMS also recommends an alternative (off-label) sequential regimen of 200mg once daily for two weeks per 28 day cycle may help to reduce administration and prescribing errors.
BMS recommends higher (off-label) doses may be required for women taking high dose oestrogen (refer to tables at top of page)
Continuous regimen: 100mg once daily on days 1–25 of each 28-day oestrogen HRT cycle (licensed dose).
BMS also recommends an alternative (off-label) continuous regimen of 100mg once daily continually.
BMS recommends higher (off-label) doses may be required for women taking high dose oestrogen (refer to tables at top of page)
Dose to be taken at bedtime (may cause drowsiness / dizziness)
Notes
Prescribe by brand (to aid identification where products contain multiple ingredients, or to prevent confusion where multiple brands contain similar ingredients).
Concomitant food ingestion increases the bioavailability of micronised progesterone.
Off-label use of Gepretix intravaginally is not supported.
Gepretix 100 mg soft capsules contain soybean lecithin and may cause hypersensitivity reactions (urticarial and anaphylactic shock in hypersensitive patients). As there is a possible relationship between allergy to soya and allergy to peanut, patients with peanut allergy should avoid using Gepretix 100mg soft capsules.
10–15mg daily for 4–6 months or longer, starting on day 5 of cycle (if spotting occurs increase dose to 20–25mg daily, reduced once bleeding has stopped)
Dysfunctional uterine bleeding or menorrhagia:
5mg 3 times daily for 10 days to arrest bleeding; 5mg twice daily from day 19 to 26 of cycle to prevent bleeding
Dysmenorrhoea:
5mg 3 times daily from day 5 to 24 of cycle, for 3–4 cycles
Postponement of menstruation:
5mg 3 times daily starting 3 days before expected onset (menstruation occurs 2–3 days after stopping)
Notes
The norethisterone 5mg preparation is not licensed or recommended for HRT.
Tibolone is not suitable for use in the perimenopause or within 12 months of the last menstrual period; women who use such preparations may bleed irregularly in the early stages of treatment—if bleeding continues endometrial abnormality should be ruled out, and consideration given to adjusting HRT. Refer to the British Menopause Society (BMS) guideline on management of unscheduled bleeding on HRT (April 2024) and the following Clinical Referral Guidelines:
For women older than about 60 years, the risks associated with tibolone start to outweigh the benefits because of the increased risk of stroke (see note 2 below).
Tibolone
Tablets 2.5mg (£3.43)
Indications
Short-term treatment of symptoms of oestrogen deficiency (including women being treated with gonadotrophin releasing hormone analogues)
Osteoporosis prophylaxis in women at risk of fractures (second-line when other prophylaxis contra-indicated or not tolerated)
Dose
2.5mg daily
Notes
Tibolone combines oestrogenic and progestogenic activity with weak androgenic activity; it is given continuously, without cyclical progestogen.
Unless the patient has a past history or may be at increased risk of thromboembolic disease:
Consider raloxifene for 5 years for postmenopausal women with a uterus at moderate or high risk of breast cancer who have severe osteoporosis or do not wish to take anastrozole or tamoxifen
Raloxifene
Tablets 60mg (£4.54 = 60mg once daily)
Indications and dose
Secondary prevention of osteoporotic fragility fractures in postmenopausal women
Adult: 60mg daily
Chemoprevention of moderate-to-high risk breast cancer in women (off-label) (refer to NICE CG164)
Adult: 60mg daily for 5 years
Notes
Raloxifene does not reduce menopausal vasomotor symptoms
Women taking raloxifene are at increased risk of thromboembolism
NICE TA160: Raloxifene is not recommended as a treatment option for the primary prevention of osteoporotic fragility fractures in postmenopausal women (February 2018)
NICE TA161: Raloxifene is recommended as an alternative treatment option for the secondary prevention of osteoporotic fragility fractures in postmenopausal women (February 2018)
who are unable to comply with the special instructions for the administration of alendronate and risedronate, or have a contraindication to or are intolerant of alendronate and risedronate and
who also have a combination of T-score, age and number of independent clinical risk factors for fracture as indicated in NICE TA161
Progesterone receptor modulators
Ulipristal acetate
Tablets 5mg
Indications
Up to 4 courses of intermittent treatment of moderate to severe symptoms of uterine fibroids in adult women who have not reached when uterine fibroid embolisation and/or surgical treatment options are not suitable or have failed (see note 4)
Periodic monitoring of the endometrium including annual ultrasound is recommended
The routine commissioning of ulipristal acetate 5mg tablets (Esmya) is accepted in Devon for up to 4 courses of intermittent treatment of moderate to severe symptoms of uterine fibroids in adult women who have not reached menopause when uterine fibroid embolisation and/or surgical treatment options are not suitable or have failed (see Commissioning Policy for more details)
MHRA Drug Safety Update (February 2021): Ulipristal acetate 5mg (Esmya): further restrictions due to risk of serious liver injury (see below):
Advice for healthcare professionals
Ulipristal acetate 5mg for uterine fibroids has been associated with cases of serious liver injury and liver failure (requiring transplantation in some cases); the licence was temporarily suspended in March 2020 to allow a further review of these risks
Although the temporary suspension has been lifted, the indication for ulipristal acetate 5mg has been further restricted – it should be used only for intermittent therapy of moderate to severe uterine fibroid symptoms before menopause and when surgical procedures (including uterine fibroid embolisation) are not suitable or failed
Ulipristal acetate 5mg should no longer be prescribed for controlling symptoms of uterine fibroids while waiting for surgical treatment
If ulipristal acetate 5mg is felt to be an appropriate therapy, talk about the risks and benefits with patients before prescribing so they can make an informed decision about treatment options; this conversation should include discussion of:
all available treatment options for moderate to severe symptoms of uterine fibroids, and the advantages and risks of these depending on personal situation
the potential risk of liver injury and liver failure with ulipristal acetate 5mg, which in rare cases has led to liver transplantation
signs and symptoms of liver injury and what to do if they occur
Continue to follow advice to monitor liver function according to the recommended schedule of liver function tests before, during, and after treatment courses. The prescriber is responsible for ensuring drug safety monitoring is undertaken
Reminder of liver function monitoring
Ulipristal acetate 5mg is contraindicated in patients with an underlying hepatic disorder.
Liver function tests must be performed before starting treatment with ulipristal acetate 5mg. Treatment must not be initiated if transaminases (alanine transaminase (ALT) or aspartate aminotransferase (AST)) exceed 2-times the upper limit of normal (ULN).
During treatment, liver function tests must be performed monthly during the first 2 treatment courses. For further treatment courses, liver function must be tested once before each new treatment course and when clinically indicated.
If a patient shows signs or symptoms compatible with liver injury (fatigue, asthenia, nausea, vomiting, right hypochondrial pain, anorexia, jaundice), treatment should be stopped, and the patient investigated immediately. Liver function tests should be performed urgently.
Stop treatment if transaminase levels (ALT or AST) are greater than 3-times the ULN and closely monitor patients. The need for specialist hepatology referral should be considered.
Liver function tests should also be performed 2–4 weeks after treatment has stopped
Advice to give to patients:
Infrequent but serious cases of liver damage (with some cases requiring a liver transplant) have been reported in association with ulipristal acetate 5mg for uterine fibroids
Ulipristal acetate 5mg can only be used for intermittent treatment of moderate to severe symptoms of uterine fibroids if:
you have not experienced menopause; and
an operation or embolisation procedure for uterine fibroids is not suitable for you or these procedures have not worked
Blood tests are needed before treatment is started, during treatment, and 2–4 weeks after treatment to check your liver is functioning normally
Stop taking your ulipristal acetate tablets and speak with your doctor immediately if you get any signs of liver damage such as yellowing of the skin or eyes, dark urine, or nausea or vomiting