Formulary

The environmental impact of inhalers

First Line
Second Line
Specialist
Hospital Only

The NHS Devon Medicines Optimisation Team has produced additional resources to support greener respiratory care across Devon, including projects to reduce carbon footprint (e.g. transitioning to lower-impact inhaler types, optimising asthma care, and promoting proper inhaler disposal), useful resources (posters, SMS templates, visual guides, leaflets, etc.), and data to support practices. This information is available on the One Devon website here.

Waste and recycling

Used pMDI canisters still contain propellants; all used pMDI canisters should be returned to a pharmacy (or dispensing GP practice) to dispose of in an environmentally safe way.

Used inhalers should not be placed in general waste.

Used inhalers that are not returned to pharmacies but are placed in general waste for kerbside collection may end up in landfill, depending on local authority arrangements. As well as plastic pollution, this risks crushing or piercing the pMDI / BAI canister and releasing additional propellants into the atmosphere.

Inhalers should be placed in the pharmacy's pharmaceutical waste bins, which are incinerated (destroying the greenhouse gases); steel and aluminium may be recovered and recycled at some incinerators. Spacers cannot currently be recycled.

Carbon footprint

Pressurised metered dose inhalers (pMDI) contain hydrofluorocarbon (HFC) propellants that do not have an effect on the ozone layer but are powerful greenhouse gases and can contribute to global warming.

Dry powder inhalers (DPI) do not use these propellants and have substantially lower global warming potential, producing 20g CO2 equivalent (CO2eq) per dose compared with 500g CO2eq for some pressurised metered dose inhalers.

Estimated carbon footprints for comparison indicate an average trip (9 miles) in a typical car produces 2,610g CO2eq (or 290g CO2eq per mile).

As Breath Actuated Inhalers (BAIs) contain the same propellants as pMDIs, the estimated carbon footprints for pMDIs can reasonably be extrapolated to BAIs. Available data consistently show that there is a significant difference between DPIs and pMDIs / BAIs, and due to the absence of HFC propellants, DPIs have a low carbon footprint compared to other inhalers.

The Respimat device is a soft mist inhaler (SMI) that does not contain propellants, and so also has a lower carbon footprint than pMDIs and BAIs.

pMDI use in England is responsible for nearly 1 million tonnes of CO2 equivalent per year.

The NHS Long Term Plan identifies a shift to lower carbon inhalers as a way of significantly reducing the carbon footprint of health and social care.

With this in mind, dry powder inhalers or soft mist inhalers are generally preferred locally, unless there is a specific clinical or dexterity reason that an individual requires a pMDI or BAI.

In young children, a pMDI and a spacer is the preferred method of delivery; a face mask is required until the child can breathe reproducibly using the spacer mouthpiece. A pMDI plus spacer is also recommended for patient of any age for the treatment of mild and moderate acute asthma attacks. Other factors to consider include the choice of drug, patient preference, and acquisition cost.

NICE has produced a patient decision aid to help people with asthma and their healthcare professionals discuss their options for inhaler devices (available here), which includes consideration of the carbon footprint of the inhaler. It is suitable for use by people aged 17 years and over, and many of the considerations are also applicable to patients with COPD.

Carbon footprint comparison tables

Data on the actual carbon footprint of individual inhalers is very limited, therefore the following tables provide indicative rather than actual values. The figures are based on usual daily doses recommended in the Devon Formulary and median CO2eq values per inhaler as estimated by PrescQIPP. Equivalent care miles for comparison have been estimated on the basis of an average trip (9 miles) in a typical car producing 2,610g CO2eq (or 290g CO2eq per mile) (see NICE).

These figures are intended to highlight the environmental impact of inhaler devices containing hydrofluorocarbon (HFC) propellants compared to dry powder / soft mist inhalers. When relevant clinical factors have been taken into account, the potential environmental benefits of selecting products with lower CO2eq per puff and/or dosing regimens that require fewer puffs per day are also noted.

Short acting beta-agonists (SABA)

Dry Powder inhalers (DPI)
Active
ingredient
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
TerbutalineBricanyl Turbohaler
4.1
Up to 4 puffs
Up to 5.99
Up to 21
Pressurised metered dose inhalers (pMDI) and breath-actuated inhalers (BAI)
Active
ingredient
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
SalbutamolSalamol CFC-free (pMDI)
60.4
Up to 8 puffs
Up to 176.37
Up to 608
SalbutamolSalamol Easi-breathe (BAI)
59.8
Up to 8 puffs
Up to 174.62
Up to 602
SalbutamolAiromir Autohaler (BAI)
48.6
Up to 8 puffs
Up to 141.91
Up to 489

Ventolin Evohaler 100 micrograms is a non-formulary product. The CO2eq per puff is 141 grams. The equivalent annual car miles for a daily dose of up to 8 puffs is up to 1,420 car miles.

Long acting beta agonists (LABA)

Dry Powder inhalers (DPI)
Active
ingredient
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
FormoterolFormoterol Easyhaler
4.53
2 puffs
3.31
11
FormoterolOxis Turbohaler
6.17
2 puffs
4.50
16
IndacaterolOnbrez Breezhaler
18.75
1 puff
6.85
24
SalmeterolSerevent Accuhaler
12
2 puffs
8.76
30
Pressurised metered dose inhalers (pMDI)
Active
ingredient
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
FormoterolAtimos Modulite
130
2 puffs
94.9
327
SalmeterolSoltel
130
4 puffs
189.8
654

Short acting muscarinic agonists (SAMA)

Pressurised metered dose inhalers (pMDI)
Active
ingredient
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
Ipratropium
bromide
Atrovent
73
3 to 8 puffs
79.94 to 213.16
276 to 735

Long acting muscarinic antagonists (LAMA)

Dry Powder inhalers (DPI) and Soft Mist Inhalers (SMI)
Active
ingredient
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
TiotropiumTiogiva (DPI)
18.75
1 puff
6.83
24
TiotropiumSpiriva Respimat (SMI)
12.92
2 puffs
9.43
33
Glycopyrronium
bromide
Seebri Breezhaler (DPI)
18.75
1 puff
6.84
24
Aclidinium
bromide
Eklira Genuair (DPI)
8.67
2 puffs
6.33
22

Combination inhalers: Inhaled corticosteroid (ICS) + Long acting beta2 agonists (LABA)

Dry Powder inhalers (DPI)
Active
ingredients
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
BDP (extrafine)/ formoterol fumarate dihydrateFostair NEXThaler1
7.41
2 to 4 puffs
5.41 to 10.82
19 to 37
Budesonide/ formoterol fumarate dihydrateFobumix Easyhaler1
4.04
2 to 4 puffs
2.95 to 5.90
10 to 20
Budesonide/ formoterol fumarate dihydrateSymbicort Turbohaler 100/6
4.83
2 to 4 puffs
3.53 to 7.05
12 to 24
Budesonide/ formoterol fumarate dihydrateSymbicort Turbohaler 200/61
6.67
2 to 4 puffs
4.87 to 9.74
17 to 34
Budesonide/ formoterol fumarate dihydrateSymbicort Turbohaler 400/12
17.75
2 puffs
12.78
44
Budesonide/ formoterol fumarate dihydrateDuoResp Spiromax1
6.8
2 to 4 puffs
4.96 to 9.93
17 to 34
Fluticasone furoate/ vilanterol trifenatateRelvar Ellipta2
26
1 puff
9.49
33
Fluticasone propionate/ salmeterolFusacomb Easyhaler
9.53
2 puffs
6.96
24
Fluticasone propionate/ salmeterolSeretide Accuhaler
15
2 puffs
10.95
38

1 estimates do not include additional “prn” use as part of MART regimens; 2 first line for COPD

Pressurised metered dose inhalers (pMDI)
Active
ingredients
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
BDP (extrafine)/ formoterol fumarate dihydrateLuforbec 100/61
101.24
2 to 4 puffs
73.90 to 147.81
255 to 510
BDP (extrafine)/ formoterol fumarate dihydrateLuforbec 200/6
119.20
4 puffs
174.03
600
Fluticasone propionate/ salmeterolAvenor
163.5
4 puffs
238.06
821

1 estimates do not include additional “prn” use as part of MART regimens

Combination inhalers: Long-acting beta2 agonists (LABA) + Long-acting muscarinic antagonists (LAMA)

Dry Powder inhalers (DPI) and Soft Mist Inhalers (SMI)
Active
ingredients
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
Indacaterol/ glycopyrroniumUltibro Breezhaler (DPI)
18.75
1 puff
6.84
24
Tiotropium bromide/ olodaterol hydrochlorideSpiolto Respimat (SMI)
12.92
2 puffs
9.43
33
Umeclidinium/ vilanterol trifenatateAnoro Ellipta (DPI)
24.00
1 puff
8.76
30
Aclidinium/ formoterol fumarate dihydrateDuaklir Genuair (DPI)
9.17
2 puffs
6.69
23
Pressurised metered dose inhalers (pMDI)
Active ingredient

Device

CO2eq per puff (g)
Daily dose
Annual CO2eq (kg)
Equivalent annual car miles
Glycopyrronium/ formoterol fumarate dihydrateBevespi Aerosphere
109.2
4 puffs
159.43
550

Triple combination inhalers: Inhaled corticosteroid (ICS) + Long-acting beta2 agonists (LABA) + Long-acting muscarinic antagonists (LAMA)

Dry Powder inhalers (DPI)
Active
ingredients
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
Fluticasone furoate/ umeclidinium/ vilanterol trifenatateTrelegy Ellipta
26
1 puff
9.49
33
BDP (extrafine)/ formoterol fumarate dihydrate/ glycopyrroniumTrimbow NEXThaler
7.41
4 puffs
10.82
37
Pressurised metered dose inhalers (pMDI)
Active
ingredients
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
BDP (extrafine)/ formoterol fumarate dihydrate/ glycopyrroniumTrimbow
118.36
4 puffs
172.81
596
Formoterol fumarate dihydrate/ glycopyrronium/ budesonideTrixeo Aerosphere
112.5
4 puffs
164.25
566

Corticosteroids

Dry Powder inhalers (DPI)
Active
ingredients
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
BudesonideEasyhaler Budesonide
3.25
2 to 4 puffs
2.37 to 4.75
8 to 16
BudesonidePulmicort Turbohaler 100
micrograms
7
2 to 4 puffs
5.11 to 10.22
18 to 35
BudesonidePulmicort Turbohaler 200
micrograms
14
2 to 4 puffs
10.22 to 20.44
35 to 70
BudesonidePulmicort Turbohaler 400
micrograms
34
2 to 4 puffs
24.82 to 49.64
86 to 171
Pressurised metered dose inhalers (pMDI) and breath-actuated inhalers (BAI)
Active
ingredients
Device
CO2eq per puff (g)
Daily dose
Annual CO2eq (Kg)
Equivalent
annual car miles
BDP
extrafine
Kelhale (pMDI)
86.64
2 to 8 puffs
63.39 to 253.57
219 to 874
BDP extrafineQvar (pMDI)
Qvar Autohaler (BAI)
Qvar Easi-breathe (BAI)
101.75
2 to 8 puffs
74.28 to 297.11
256 to 1,025
BDPClenil Modulite (pMDI)
81.90
2 to 8 puffs
59.78 to 239.15
206 to 825