Formulary

Management of community multidrug-resistant (MDR) urinary tract infection (UTI)

First Line
Second Line
Specialist
Hospital Only
If GFR <45mL/min
Pivmecillinam
  • Consider pivmecillinam if eGFR less than 45mL/min
  • 400mg single dose on day one then 200mg every 8 hours for 3 days in women, 7 days in men
  • This is an extended-spectrum penicillin antibiotic
If high risk of resistance
Fosfomycin
  • Consider fosfomycin if high risk of resistance to first line options
  • Female: 3g sachet as a single dose
  • Male: 3g sachet initial dose and repeat after 3 days; unlicensed but in line with PHE guidance
  • Doses should be taken preferably before bedtime and after emptying the bladder