Doxycycline

• Capsules 50mg (£1.56 = 28 capsules), 100mg (£1.15 = 8 capsules)
• Dispersible tablets sugar free 100mg (£4.91 = 8 dispersible tablets)
• Modified-release capsules 40mg (£15.98 = 28 capsules)

Indications

• Upper respiratory tract infections:
  • Acute sinusitis
    • Penicillin allergy in adults/ children and young people over 12 years - (second line)
• Lower respiratory tract infections:
  • Acute cough, bronchitis
    • Adults aged 18 years and over
    • Children and young people over 12 years - (second line)
  • Acute exacerbation of COPD
    • Adults aged 18 years and over
  • Community acquired pneumonia
    • Penicillin allergy in adults/ children and young people over 12 years - (second line)
• Non-cystic fibrosis bronchiectasis (acute exacerbation)
  • Adults/ children and young people over 12 years
• Urinary tract infections:
  • Chronic Pelvic Pain Syndrome
    • Adults aged 18 years and over - (second line)
• Genital tract infections:
  • Chlamydia trachomatis
    • Adults/ children and young people over 12 years
  • Pelvic inflammatory disease
    • Adults/ children and young people over 12 years
      • plus ceftriaxone IM and metronidazole or
      • plus metronidazole (second line) (oral regime only)
• Skin and soft tissue infections:
  • Infected eczema
    • Penicillin allergy in adults/ children and young people over 12 years - (second line)
  • Bites (Human or Animal) 
    • Penicillin allergy in adults/ children and young people over 12 years – plus metronidazole (second line)
  • Lyme disease
    • Adults/ children and young people over 9 years (off-label)
  • Boils, carbuncles, folliculitis and paronychia - (second line)
• Moderate to severe acne 
  • Adults/ children and young people over 12 years - plus Epiduo OR Azelaic acid
• Rosacea
• Falciparum malaria - (specialist input)

Notes

1. Doxycycline 40mg is included for the treatment of rosacea
2. Dispersible tablets are considerably more expensive than capsules and should be reserved for use only in individuals who are unable to swallow capsules

Lymecycline

• Capsules 408mg (£4.09 = 28 capsules, £7.98 = 56 capsules)

Indications

• Moderate to severe acne
  • Adults/ children and young people over 12 years - plus Epiduo OR Azelaic acid
• Rosacea (off-label)

Oxytetracycline

• Tablets 250mg (£1.21 = 28 tablets)

Indications

• Moderate to severe acne
  • Adults/ children and young people over 12 years - plus Epiduo OR Azelaic acid

Demeclocycline hydrochloride

• Capsules 150mg (£238.41 = 28 capsules)

Notes

1. Demeclocycline is not used for the treatment of infection, but is used in the management of inappropriate secretion of antidiuretic hormone.

Tigecycline

• Powder for solution for infusion vial 50mg

Minocycline

Following national guidance from NHS England, minocycline is not recommended for use for the treatment of acne due to an increased risk of adverse effects such as drug induced lupus, skin pigmentation and hepatitis. Click here for more information. Prescribers should not initiate minocycline for acne for any new patient.